Pregled bibliografske jedinice broj: 297315
Interaction of pyridinium oximes with acetylcholinesterase and their effect on organophosphate-poisoned mice
Interaction of pyridinium oximes with acetylcholinesterase and their effect on organophosphate-poisoned mice // Journal of molecular neuroscience, 30 (2006), 1/2; 113-114 doi:10.1385/JMN:30:1:113 (međunarodna recenzija, članak, znanstveni)
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Naslov
Interaction of pyridinium oximes with acetylcholinesterase and their effect on organophosphate-poisoned mice
Autori
Kovarik, Zrinka ; Čalić, Maja ; Lucić Vrdoljak, Ana ; Radić, Božica
Izvornik
Journal of molecular neuroscience (0895-8696) 30
(2006), 1/2;
113-114
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
acetylcholinesterase; antidote; nerve agent; inhibition; reactivation; oxime; antidotal treatment
Sažetak
The progresive inhibition of acetylcholinesterase (AChE, EC3.1.1.7)by organophosphates (OPs), such as nerve agents tabun and soman, is due to phosphorylation of the active center serine characterized by the formation of conjugates and inactivation of this essential enzyme involved in neurotransmission. We investigated the interactions of five bispyridinium oximes with human erythrocyte AChE and their effects on tabun-and soman-poisoned mice.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb
Profili:
Maja Katalinić
(autor)
Ana Lucić Vrdoljak
(autor)
Božica Radić
(autor)
Zrinka Kovarik
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
