Naslov
New Acyclic Purine Nucleoside Analoques Containing Exocyclic Pyrrolo Moiety: Synthetic and X-Ray Crystal Structure Study

Autori
Raić, Silvana ; Pongračić, Mario ; Vorkapić-Furač, Jasna ; Hergold-Brundić, Antonija ; Nagl, Ante ; Mintas, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Izvornik
The tenth Dubrovnik International Course and Conference on the Interfaces among Mathematics, Chemistry and Computer Sciences : abstracts / - , 1995

Skup
Dubrovnik International Course and Conference on the Interfaces among Mathematics, Chemistry and Computer Sciences

Mjesto i datum
Dubrovnik, Hrvatska, 26.06.1995. - 01.07.1995

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
aciklički purinski nukleozidni analozi ;
(acyclic purine nucleoside analogues ; potential antiviral agents)

Sažetak
There has been considerable interest in nucleosites modified on the sugar moiety as potential antiviral agents. The search for new antiviral drugs led to the synthesis of a large number of acyclic nucleosides. Furthermore, adenine analofues have been used as plant growth factors (cytokinines) important for plant cell division and differentiation. In the search of molecules related to those classes of biologically and pharmacologically active compounds and in continuation to our previous research in this field, we have prepared the novel 6-(N-pyrroly) purine nucleoside analogues l -7 with acyclic side chains attached to the N-9 position of the purine ring. The site of alkylation of the purine ring was deduced on the basis of their lH and 13C NMR spectra. The conformation of the dimeric structure 6 was determined by its X-ray crystalographic analysis.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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