Naslov
Enantiomers and Barriers to Racemization of Chiral Heterocyclic Biaryls

Autori
Vorkapić-Furač, Jasna ; Mintas, Mladen ; Schuster, David ; Mannschreck, Albrecht

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Sixth European Symposium on Organic Chemistry

Mjesto i datum
Beograd, Srbija, 1980

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
kiralni heterolitički biarili
(chiral heterocyclic biaryls; barrier to racemization)

Sažetak
In connection with our previous studies on some chiral N-aryl-pyrroles1 we have prepared novel, sterically hindered N-aryl-3-formyl- l-2, 5-dimethylpyrroles (l-2) ; 3-formyl -2, 5-dimethyl-N-(2-thiazolyl) pyrrole (3) ; 3-formyl-2, 5-dimethyl_N (8-quinolyl) pyrrole (4) and 3-formyl-2, 5-dimethyl-N (6-puriny)pyrrole (5), needed for the study of substituent effects upon the barriers to racemization. As a consequence of restricted rotation about the C-N bond the ground state of l-5 is nonplanar, l.e.chiral.Separation of enantiomers (M) and (P) of l and 2 was achieved by liquid chromatography on optically active triacetylcellulose. Lower limit of the barrier to racemization in 2 was estimated.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA