Naslov
Chromosome aberrations in coeliac and non-coeliac enteropathies

Autori
Kolaček, Sanja ; Petković, Iskra ; Booth, Ian Westerby

Izvornik
Archives of Disease in Childhood (0003-9888) 78 (1998), 5; 466-468

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
coeliac disease; chronic enteropathy; chromosomal aberrations

Sažetak
The frequency of chromosomal aberrations in peripheral blood lymphocytes was assessed in three groups of children: untreated coeliac disease (n=20); non-coeliac disease enteropathies (n=15); controls (n=15). The mean frequency of aberrant cells and the total number of aberrations per 100 metaphases was increased in the coeliac disease group compared with controls by factors of 5 and 6, respectively (p<0.01, for both). Aberrant cells and total aberrations were similarly increased in the non-coeliac disease enteropathy group by a factor of 3.7 in each case (p<0.05). However, the frequency of aberrations in the two enteropathy groups was not significantly diferrent. Children with coeliac disease, similar to affected adults, have evidence of increased chromosomal instability. However, similarly increased chromosomal aberrations are seen in children with non-coeliac disease enteropathies, indicating that the abnormality is not specific for coeliac disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA