Formylation of 2, 5-Unsubstituted Oxazole: Preparation and Characterization of 2- and 5-Formyl-4-Methyloxazoles

Šindler-Kulyk, Marija; Vojnović, Dragana; Defterdarović, Nafis; Marinić, Željko; Srzić, Dunja

Pregled bibliografske jedinice broj: 294486

Formylation of 2, 5-Unsubstituted Oxazole: Preparation and Characterization of 2- and 5-Formyl-4-Methyloxazoles

Šindler-Kulyk, Marija; Vojnović, Dragana; Defterdarović, Nafis; Marinić, Željko; Srzić, Dunja

Formylation of 2, 5-Unsubstituted Oxazole: Preparation and Characterization of 2- and 5-Formyl-4-Methyloxazoles // Heterocycles, 38 (1994), 8; 1791-1796 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 294486 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Formylation of 2, 5-Unsubstituted Oxazole: Preparation and Characterization of 2- and 5-Formyl-4-Methyloxazoles

Autori
Šindler-Kulyk, Marija ; Vojnović, Dragana ; Defterdarović, Nafis ; Marinić, Željko ; Srzić, Dunja

Izvornik
Heterocycles (0385-5414) 38 (1994), 8; 1791-1796

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
oxazole ; methyloxazole ; formylation ;
(oxazole ; methyloxazole ; formylation)

Sažetak
Vilsmeier formylation of 4-methyloxazole (1) gave a mixture of 4-methyl-5-oxazolecarboxaldehyde (2) and 4-metyl-2-oxazolecarboxaldehyde (3) in l:l ratio. Both aldehydes were prepared nambiguously: adehyde (2) by oxidation of 5-hydroxymethyl-4-methyloxazole (4) and reduction of chloride of 4-methy-5-oxazolecarboxylic acid (5) and aldehyde (3) by n-butyllithium/DMF procedure. Aldehyde (2) sublimes in a refrigerator while aldehyde (3) forms hydrate, 5-dihydroxymethyl-4-methyloxazole (8).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Željko Marinić (autor)