Naslov
Cathepsin D content in endometrial carcinoma

Autori
Babić, Damir ; Osmak, Maja ; Abramić, M. ; Miličić, Duško ; Jukić, Stanko ; Ilić-Forko, Jadranka ; Kos, Marina ; Nola, Marin ; Vrhovec, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstract / Unknown - : Unknown, 1997

Skup
Internatiol meeting of Quantitative pathology

Mjesto i datum
Siena, Italija, 1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Cathepsin D; endometrial carcinoma

Sažetak
The aim of this study was to determine the concentration of cathepsin D in normal uterine tissue and endometrial carcinoma (30 matched pairs), and to assess the relationship between Cathepsin D content and clinical and pathohistological prognostical parameters in uterine carcinomas. The samples representing matched pairs were obtained from the tumour and adjacent normal tissue. The cathepsin D content was measured in cytosol of homogenated samples, using a commercially available solid-phase two-site immunoradiometric assay (CIS Bio International, Gif-sur-Yvette, France). The total protein in cytosol was determined by Bradford-s method. We found that the concentrations of cathepsin D were significantly higher in tumours (35,0ą19,02 pmol/mg protein) than in normal tissue (11,87ą5,21 pmol/mg protein) p< 0.001 with a tumour to normal tissue ratio of 2,95. The concentrations of cathepsin D did not seem to relate to clinical stage (I versus II and III), myometrial invasion, tumour grade, histological type of tumour, lymphovascular invasion, and patients age.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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