Naslov
Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma

Autori
Tomas, Davor ; Ulamec, Monika ; Hudolin, Tvrtko ; Bulimbašić, Stela ; Belicza, Mladen ; Krušlin, Božo

Izvornik
Prostate cancer and prostatic diseases (1365-7852) 9 (2006), 4; 414-419

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
myofibroblasts; tenascin-C; laminin; prostate adenocarcinoma

Sažetak
The aim of this study was to analyse relationship between changes of the stroma and expression of tenascin-C (TN-C) and laminin in prostate carcinoma. Tenascin-C immunostaining was increased, and laminin decreased in carcinomas compared with peritumoral tissue and benign prostate hyperplasia (p<0.05). Statictical analysis confirmed connection between stromal changes and TN-C expression in prostate carcinoma (p<0.05). Gleason pattern 3 carcinomas showed more pronounced stromal reaction and TN-C expression compared with Gleason pattern 4 carcinomas (p<0.05). The main cells in prostate cancer stroma are myofibroblasts that are also responsible for tenascin production. Degreadation of laminin was not connected with myofibroblastic stromal changes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA