Naslov
Different Types of Atrophy in the Prostate with and without Adenocarcinoma

Autori
Tomas, Davor ; Krušlin, Božo ; Rogatsch, Hermann ; Schaefer, Georg ; Belicza, Mladen ; Mikuz, Gregor

Izvornik
European Urology (0302-2838) 51 (2007), 1; 98-104

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
proliferative atrophy; proliferative inflammatory atrophy; prostate adenocarcinoma

Sažetak
Objectives: The purpose of this study was to evaluate, according to a classification proposed by a working group, the extent and type of atrophy lesions in radical prostatectomy specimens obtained from patients with prostatic carcinoma and benign prostatic hyperplasia (BPH) and to compare the prevalence and types of atrophy between two investigated groups. Methods: Histologic analysis of 1096 slides fro 50 patients with carcinoma and 277 slides from 31 patients with BPH was performed to evaluate, according to the new prostatic atrophy classification, the number of foci and type of atrophic lesions. Results: Age, Gleason grade, and TNM showed no significant correlation wuth the number of proliferative atrophy (PA) and proliferativeinflammatory atrophy (PIA) poci (p>0.05). PIA was significantly more frequent in prostates with carcinoma (1.63 vs 1.27 atrophic lesions per slide) (p<0.001), whereas PA displayed an increased frequency in BPH (2.28 vs 0.76 atrophic lesions per slide) (p<0.001). Conclusions: We confirmed that PA and PIA are common findings in prostates with and without carcinoma, but the question of whether inflammation produces tissue damage and PA or whether some other insult induces the tissue damage and atrophy directly, with inflammation occuring secondarily, is still unresolved.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA