Naslov
Rageneration of articular cartilage defects in rabbits by Osteogenic Protein -1(Bone Morphogenetic Protein - 7)

Autori
Grgić, Marko ; Jelić, Mislav ; Bašić, Nikolina ; Bašić, Vanja ; Pećina, Marko ; Vukičević, Slobodan

Izvornik
Acta Medica Croatica (1330-0164) 51 (1997); 23-27

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Rabbits; bone morpogentic protein - 7; Osteogenetic protein - 1

Sažetak
Osteogenic protein-1 (OP-1, BMP-7), a member of the transforming growth factor-beta family, induces cartilage and bone formation when implanted at intra and extraskeletal sites in vivo. The human OP-1 gene has been cloned and biologically active recombinant OP-1 homodimers have been produced. In the present study, the authors investigated the influence of OP-1 on healing of full-thickness articular cartilage defects, made by drilling two adjacent (phi 3mm) holes through articular cartilage of NZW rabbit knee joint were dissected and examined histomorphometrically. Results indicated that OP-1 induced articular cartilage healing and regeneration of the joint surface which contained cells resembling mature joint chondrocytes. These data imply a new strategy for biological repair of damaged joint surfaces in humans

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA