Naslov
Toxicokinetic of Cadmium after Treatment with Calcium and Selenium Compounds

Autori
Matek Sarić Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts 2nd Central European 5th Croatian Congress of Food Tehnologists, Biotehnologists and Nutritionist / - Zagreb, 2004

Skup
2nd Central European 5th Croatian Congress of Food Tehnologists

Mjesto i datum
Opatija, Hrvatska, 17.-21.10

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Cadmium absorption; calcium supplemention; selenium supplemention; oral; parenteral exposure

Sažetak
The study evaluates the effect of calcium and selenium supplementation on tissue cadmium concentration after oral or parenteral exposure to cadmium. The experiments were done on 5-7 weeks old female or 6-15 days old suckling Wistar rats. The 5-7 weeks old female received calcium and selenium supplementation by stomach tube in volume of 0, 5 ml distilled water. The suckling rats received each supplementations in cow  s milk by artificial feeding from day of birth 6 through 14. Cadmium and essential elements ( Fe, Zn and Cu) were analysed in organs ( liver, kidneys, brain) and carcasses (body without organs and skin) by atomic absorption spectrometry (Varian AA-375, Australia). Deuterium backgraund correction was applied. To verify our chemical analyses certified standard reference material Bovine liver SRM 1577b from National Institute for Standards and Tehnology (USA) was analysed by the same procedure as the samples from the experiments. Results showed that after oral exposure cadmium concentrations in all calcium-supplemented groups were significantly decreased in the organs and carcass and the effect was dose-related. No such effect of calcium was found after parenteral cadmium exposure. Calcium supplementation per se significantly increased calcium concentration in the carcass and had no effect on iron in organs and zinc in carcass. It was concluded that calcium supplementation during the suckling period could be an efficient way of reducing oral cadmium absorption and retention without affecting tissue essential trace element concentrations. Nine-day oral treatmant with selenium and concomitant oral exposure to cadmium had no effect on cadmium tissue concentration in both suckkling and older rats.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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