Naslov
Novel numerical and graphical representation of DNA sequences and proteins

Autori
Randić, Milan ; Novič, Marjana ; Vikić-Topić, Dražen ; Plavšić, Dejan

Izvornik
Sar and Qsar in Environmental Research (1062-936X) 17 (2006), 6; 583-595

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA sequence; protein; numerical representation; graphical representation; 8×8 table of codons; virtual genetic code

Sažetak
We have introduced novel numerical and graphical representations of DNA, which offer a simple and unique characterization of DNA sequences. The numerical representation of a DNA sequence is given as a sequence of real numbers derived from a unique graphical representation of the standard genetic code. There is no loss of information on the primary structure of a DNA sequence associated with this numerical representation. The novel representations are illustrated with the coding sequences of the first exon of β -globin gene of half a dozen species in addition to human. The method can be extended to proteins as is exemplified by humanin, a 24-aa peptide that has recently been identified as a specific inhibitor of neuronal cell death induced by familial Alzheimer's disease mutant genes.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA