Naslov
Bartters syndrome - case report

Autori
Glavina-Durdov, Merica, Ljutić, D, Šćukanec-Špoljar, Mira

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstract book of 1st Congress of the croatian society for electron mictroscopy / Vranešić, Đuro - Zagreb : Hrvatsko društvo za elektronsku mikroskopiju, 1999, 33-34

Skup
1st Congress of the croatian society for electron microscopy with international participation

Mjesto i datum
Zagreb, Hrvatska, 13.05.1999. - 16.05.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Bartters syndrome; metabolic alkalosis

Sažetak
Aim. Forty years old female suffered for long term weakness, persistent unexplained hypokalemia, metabolic alkalosis and cryoglobulinemia(Table 1).The serum value of aldosterone was in the normal range.According to hyperreninemia, clinical suspicion of Bartters syndrome was established and percutaneous renal biopsy was performed.The patient was treated with spironolactone, nonsteroid antinflammatory drug and oral potassium supplementation. Methods. Percutaneous renal biopsy tissue specimen was prepared in standard manner for rutine light and ultrastructural analysis. Results. All glomeruli shopwed global hypertrophy of juxtaglomerular apparatus.Except a mild focal mesangial proliferation, other glomerular structures as well as tubules, interstitium and blood vessels were normal(Figures 1 and 2).On semithin section only one glomerulus was found and cut to show juxtaglomerular apparatus.Ultrastructurally, numorous dense core neurosecretory granules and progranules were found in the cytoplasm of juxtaglomerular cells(Figure 3). Conclusion. Although Bartter syndrome is rare, the diagnosis should be entertained in normotensive patient with unexplained persistent hypokalemia and hyperreninemia and confirmed morphologically as hyperplasia and hypergranularity of juxtaglomerular cells.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA