Naslov
Investigation of diffuse mesangial proliferative glomerulonephritis in children

Autori
Ćorić, Marijana ; Šćukanec-Špoljar, Mira ; Čužić, Snježana ; Batinić, Danica ; Matković, Maja ; Batinić, Danko ; Grković, Lana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Meeting abstract of 19th European Congress of Pathology / - , 2003, 378-378

Skup
19th European Congress of Pathology

Mjesto i datum
Ljubljana, Slovenija, 06.11.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
mesangial proliferative glomerulonephritis

Sažetak
Introduction.Pure diffuse mesangial proliferative glomerulonephritis(MEPGN), although one of the basic light microscopic(LM)structural glomerular lesions, is morphologically highly nonspecific, and additional investigations are needed to reach the final diagnosis(dg)of disease.We studied the value of immunofluorescence(IF)and electzron microscopy(EM)for dg, and which proportion of cases represent an idiopathic form of disease. Material and methods.We reviewed clinical picture, IF and EM findings in 154 children with MEPGN in LM. Results.50 presented as nephrotic syndrome(NS), 67 as proteinuria and/or microhematuria(P/MH), 10 as recurrent hematuria(RH), 20 cases were clinically identified as purpura(P)and 7 as SLE.IF revealed 22 cases of Berger disease, while in 105 cases IF was negative or nonspecific(46 NS, 55 P/MH, 4 RH).EM revealed 7 cases of thin basement membrane disease, all with MH, and 33 cases with GBM lesions consistent with Alport syndrome(29 P/MH, 2 RH, 2 NS).21 patients showed EM features of resolving acute GN, all with P/MH, while residual 93 showed MEPGN with or without mesangial deposits(42 NS, 22 P/MH, 2 RH, 20 P, 7 SLE). Conclusion.By means of clinical data, IF and EM, it was possible to reach definite dg in 110(71.4%)cases.Among residual 28.6% with negative/nonspecific IF and MEPGN in EM, there were 36 cases of NS belonging to idiopathic but clinically well-defined childhood nephrosis.So, only 8 cases represented a truly non-defined category of MEPGN(5.2% of all cases).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA