Naslov
Infertility and therapy with immunoglobulins

Autori
Duić, Željko ; Singer, Zvonimir ; Podobnik, Mario ; Ciglar, Srećko ; Podgajski, Mario ; Rabatić, Sabina ; Humar, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
American journal of reproductive immunology 46(1) / - , 2001, 108-108

Skup
VIII International Congress of Reproductive Immunology.

Mjesto i datum
Opatija, Hrvatska, 02.07.2001. - 06.07.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
immunotherapy ; spontaneous abortion ; intravenous immunoglobulin(IVIG)

Sažetak
Registration complication, side effects, and results of intravenous immunoglobulins therapy (IVIG), determination peripheral serum levels of TNF Alfa and IL-2 in pregnancies with history of recurrent spontaneous abortion. Study design: A prospective study in 35 women with habitual abortions in the first trimester. Indications for including in study were ; excluding anatomical, endocrinological, genetic, microbiological and other environmental cause of infertility in couples sharing HLA-D antigens. Results: Out of 35, twenty four pregnancies have finished with twenty six healthy live born babies. One triplets were born in 35th week of gestation by caesarean section, they were conceived after induction ovulation and ICSI. One baby was born in 28th week of gestation by caesarean section. This baby died three hours later. Ten have miscarried. That means the possible successful rate of treatment would be 71, 42% (25/35). Six miscarriages were in the first trimester of gestation without known reasons. One pregnancy finished in first trimester due to chromosome mosaicisms of product of conception, another one due to submucosal mioma. Two abortions were in second trimester due to partial septate uterus, and another due to cervical incompetence. Last three mentioned cases were results of wrong selection or wrong following control. If we exclude these cases and known chromosomal reasons of abortion, successful rate of therapy with IVIG will be 80, 64% (25/31). Cervical cerclages and caesarean sections were in normal range. Control laboratory and clinical examinations of the successful pregnancies were always normal. The side effects of treatment with IVIG occurred only during first infusion, but minor, in eleven cases. Conclusions: Real value of immunoglobulins therapy will be possible evaluated after meta analysis of more number of treated cases.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA