Naslov
Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis (JIA).

Autori
Jelušić, Marija ; Tambić-Bukovac, Lana ; Lukić, Ivan Kresimir ; Dubravčić, Klara ; Malčić, Ivan ; Batinić, Drago

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / - , 2006

Skup
European Academy of Paediatrics

Mjesto i datum
Barcelona, Španjolska, 07.10.2006. - 10.10.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
juvenile idiopathic arthritis; IL-10; IL-18

Sažetak
Objective: To explore the balance between serum and synovial fluid levels of interleukin-10 (IL- 10) and IL-18 in children with juvenile idiopathic arthritis (JIA). Methods: Blood samples were obtained from 81 child with JIA and 18 control children. Synovial fluid samples were collected from 16 children with pauciarticular JIA. Concentrations of IL-10 and IL-18 were determined using commercial kits. Results: Patients with systemic JIA had higher serum levels of IL-18 than patients with other forms of JIA or control children, both during the active (median, range: 6065, 387 – 78750 pg/mL) and inactive (1523, 121 – 3270 pg/mL) phase of disease (ANOVA, P<0.05). Levels of IL-18 in sera of children with pauciarticular JIA (255, 89 – 4342 pg/mL) were similar to the corresponding synovial fluid levels (217, 89 – 1245 pg/mL). Serum levels of IL-18 were proportional to the erythrocyte sedimentation rate and levels of C-reactive protein, but inversely proportional to the haemoglobin levels. Clinical remission was characterised by higher serum levels of IL-10 in children with systemic JIA (ANOVA, P < 0.05 vs. the other groups) while the differences during the active phase were not significant. Moreover, synovial levels of IL-10 in patients with pauciarticular JIA (20.8, 1.6 – 67.6 pg/mL) were higher than serum levels of IL-10 in the same patients (3.0, 0.0 – 32.7 pg/mL) (t-test, P<0.05). Conclusion: As IL-18 appears to be an important mediator of systemic JIA, its inhibition should be a base for a successful therapeutic approach. Role of IL-10 in pathogenesis of JIA is less clear, but it seems to be predominantly involved in local, rather than systemic pathogenetic processes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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