Naslov
Relation between urinary cytology abnormalities and Cyclosporine A therapy in bone marrow transplant recipients

Autori
Sučić, Mirna ; Boban, Dubravka ; Marković-Glamočak, Mirjana ; Bogdanić, Vinko ; Nemet, Damir ; Labar, Boris ; Čvoriščec, Dubravka ; Plavšić, Franjo ; Štoos-Veić, Tajana ; Mrsić, Mirando

Izvornik
Renal failure (0886-022X) 20 (1998), 4; 613-620

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
bone marrow transplantation ; Cyclosporine A ; urine cytology

Sažetak
The aim of the study was to determine the relationship, if any, between abnormalities in urinary cytology and the administration of cyclosporine A in bone marrow transplant recipients. Specific attention was given to the presence of tubular cells with round inclusions (TCRI) Two bone marrow transplant recipient groups were studied: one with allogeneic bone marrow transplantation (BMT) (20 patients) who were treated with cyclosporine A, and the other with autologous BMT (12 patients) who did not receive cyclosporine A. Urinary cytology showed TCRI in 41.66% of the patients after autologous BMT and in 80% of the patients after allogeneic BMT. In the group of patients treated with allogeneic BMT, the occurrence of TCRI was associated with a high incidence of glycosuria and was followed by an increase in the blood level of cyclosporine A, an increase in the serum creatinine concentratin and a decrease in the creatinine clearance. These results demonstrated that TCRI, although related to, were not found to be exclusively specific to the administration of cyclosporine A.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA