Naslov
Recombinant human bone morphogenetic protein-7 (rhBMP-7) in the treatment of scaphoid nonunions with proximal pole sclerosis

Autori
Bilić, Luka ; Smoljanović, Tomislav ; Bilić, Ranko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Liječnički vjesnik ; (128) ; Suplement 8 ; 6th ZIMS Abstract Book / Anić, Branimir - Zagreb : European Maritime Safety Agency (EMSA), 2006

Skup
6th Zagreb International Medical Summit

Mjesto i datum
Zagreb, Hrvatska, 09.11.2006. - 12.11.2006

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
scaphoid nonunion; BMP-7; Matti-Russe

Sažetak
The aim of this clinical study was to test if the rhBMP-7 could enhance radiographic and clinical healing and removal of sclerosis in scaphoid non-unions containing sclerotic bone. Eighteen patients with scaphoid non-union at the proximal pole were randomly assigned to three treatment groups: (I) autologous iliac bone graft (n=6), (II) autologous iliac bone graft with rhBMP-7 (n=6), and (III) allogeneic iliac bone graft with rhBMP-7 (n=6). Clinical, radiographic, and scintigraphic assessments were performed throughout the follow-up period of 24 months. Performance of both autologous and allogeneic bone implants were improved by rhBMP-7. Radiographic healing time was reduced from 9 weeks in group without rhBMP-7 to 4 weeks in groups with rhBMP-7. Replacement of sclerotic bone by well-vascularised bone in rhBMP-7 treated patients was confirmed with helical CT scans and scintigraphy. The application of rhBMP-7 with an allograft bone implant equalized the clinical outcome in healing of the scaphoid non-union with the autologous graft procedure. Use of an allograft avoids autograft donor site morbidity and results in a shorter postoperative immobilization and consequently better clinical results.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA