Naslov
Sleep and Parkinson disease: preliminary results

Autori
Klepac, Nataša ; Relja, Maja

Izvornik
Journal of neurology (0340-5354) 253 (2006); 140-X

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
PD ; PSQI ; tremor ;
(PD ; PSQI ; tremor)

Sažetak
Background: The sleep disturbance occurs frequently in Parkinson’ disease (PD). The cause of sleep disorders in PD is multifactorial, including the neurodegenerative changes affecting sleep centres and persistence of PD symptoms at night. Objective: The aim of present study was to evaluate the characteristics of sleep problems and different subtypes of PD. Patients and Methods: A consecutive series of eighty-three PD patients (39 men, 44 women) with a mean age of 61.2 ± 9.2 years, PD duration of 5.3 ± 5.4 years, mean Hoehn&Yahr stage of 2.2± 0.5 who fulfilled the criteria for idiopathic PD were included the study. Motor performance was evaluated using the motor section of the Unified Parkinson’ s Disease Rating Scale (UPDRS). The severity of insomnia was assessed using the Pittsburgh sleep quality index (PSQI). Daytime sleepiness was evaluated with Epworth sleepiness scale (ESS). Patients were divided according to akinesia and tremor score on UPDRS in group of akinetic rigid subtype or tremor subtype. The tremor dominant subtype of PD was defined as patients with a ratio of tremor to bradykinesia score of 0.5 or more, and the akinetic rigid subtype as patients with a ratio of <0.05. Results: Fifty-four (65%) patients belonged to akinetic rigid subtype and 29 (34.9%) patients to tremor subtype. There were no significant differences between groups regarding the age and duration of disease (Mann Whitney, p>0.05). Patients with predominance of akinetic-rigid features had worse quality of sleep than tremor dominant patients (13.6± 3.7, 8.5± 3.8 ; Mann Whitney, p<0.05) according to PSQI. This was evident in several different domains ; subjective sleep quality, sleeps duration, sleeps latency and sleep disturbances. There was no difference in daytime sleepiness according to scores obtained on ESS. Conclusion: Our preliminary results suggest that the akinetic subtype of PD is associated with more sleep disturbances. This could be due to nocturnal immobility that interferes with normal sleep architecture. Clinician should pain attention on this group of patients regarding sleep quality.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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