Naslov
Modelling and Optimisation of Central Metabolism Response to Glucose Pulse

Autori
Čerić, Sonja ; Kurtanjek, Želimir

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of Information Technology Interfaces, ITI 2006 / Vesna, Lužar-Stiffler ; Vesna Dobrić-Hljuz - Zagreb : Sveučilišni računski centar Sveučilišta u Zagrebu (Srce), 2006, 501-506

Skup
Inoformation Technology Interfaces 2006

Mjesto i datum
Cavtat, Hrvatska, 18.06.2006. - 22.06.2006

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
metabolic networks; Nedler-Mead; simulated annealing; differential evolution

Sažetak
The application of global optimisation algorithms for modelling of enzyme kinetics and parameters of the central metabolism is analyzed. The model is a set of 10 highly complex stiff ordinary differential equations with 132 adaptive parameters. The efficacies of Nedler- Mead, simulated annealing, and differential evolution for minimization of variance between simulations of a model of the central metabolism and experimental data of the corresponding intracellular key metabolites are compared. Experimental data obtained during response of population of E. coli cultivated in a batch bioreactor are applied. Data are obtained during transients of 15 seconds upon a glucose impulse. Results are discussed in view of metabolic flux analysis and genetic engineering.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA