Naslov
Neurotoxic Influence on Sonographic Findings of Nigral Substance in Parkinsons Disease (PD)

Autori
Lovrenčić Huzjan, Arijana ; Budišić, Mislav ; Bošnjak, Jelena ; Trkanjec, Zlatko ; Lisak, Marijana ; Vuković, Vlasta ; Antić, Sonja ; Demarin, Vida

Izvornik
Cerebrovascular diseases (1015-9770) 21 (2006), 3; 39-40

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
Neurotoxic influence ; sonography ; nigral substance ; Parkinson's disease

Sažetak
Aim: We initiated this study to detect possible neurotoxic influence on clinical course, disease characteristics and morphology of Nigral substance (NS) in PD patients. Patients: Study included 26 PD patients without any data about exposure to known PD related toxins, 15 PD patients occasionally exposed and 6 patients professionally daily exposed to numerous neurotoxic potent chemicals. Epidemiological screen data included exposure to pesticides, herbicides, heavy metals (manganese, mercury, lead, iron, zinc), organic solvents, head trauma, smoking, rural living and well water drinking. Methods: All PD patients underwent complete neurological and sonographic examination. Each patient underwent brain parenchyma sonography and hyperechogenicity of NS was measured. We compared age of PD onset, UPDRS and H&Y score, levodopa dosage, time between PD diagnosis was established and onset of late motor complications, dominating symptoms and sonographic results. Intergroup comparison was done with Students t test. Results: Our results showed younger age of PD onset (p<0.05), the fastest development of late motor complications (p<0.05), rigor as motor disability (p<0.05) in highly exposed group. However, sonographic examination revealed no statistically significant difference in NS echogenicity between groups. Discussion: Although increased echogenicity appears to be constant feature of PD, data obtained in this study suggest that toxic influence does not have influence on NS size. Results of this study also suggest that exposure to toxins could cause younger age of onset of PD, acceleration of PD progression and higher incidence of motor disability.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA