Naslov
Relationship between serum antibody profiles against Helicobacter pylori and gastroduodenal disease outcome

Autori
Filipec-Kanižaj, Tajana ; Katičić, Miroslava ; Presecki, Vladimir ; Prskalo, Marija ; Tićak, Mirjana ; Šabarić, Branka, Naumovski-Mihalic, Slavica ; Čolić-Cvrlje, Vesna ; Škurla, Bruno

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Gut / Robin C. Watson - London : Delhi : British Medical Journals, 2006

Skup
14th UEGW

Mjesto i datum
Berlin, Njemačka, 21.10.2006. - 25.10.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori; serology; outcome

Sažetak
INTRODUCTION: Infection with Helicobacter pylori is associated with development of a variety of gastroduodenal diseases. Although Helicobacter pylori is common, the development of peptic ulcer disease and gastric carcinoma strikes only a small percentage of carriers.We evaluated the antibodies profiles to Helicobacter pylori virulence proteins to determine a relation between host response and outcome of infection. AIMS & METHODS: The study was conducted on 207 patients undergoing upper endoscopy. The Western blot method was applied to determine the presence of antibodies to p 120 (CagA), p 95 (VacA), p 67 (FSH), p 66 (UreB), p 57 (HSP homolog), p 54 (flagelin), p 33, p 30 (OMP), 29 (UreA), p 26, p19, and p17 proteins of Helicobacter pylori bacteria in the serums of Helicobacter pylori positive patients. The patients were assigned to gropus according to the diagnosis: 46 patients had gastric ulcer, 68 duodenal ulcer, 30 carcinoma, 12 gastric and duodenal ulcer and 51 were diagnosed as non 2 test (STATISTICA ulcer dispepsia. Statistical analysis was performed using for Windows, Release 5.5 H i SPSS for Windows, Release 7.5). RESULTS: P95 (VacA) seropositivity was more freequent in duodenal ulcers and non ulcer dispepsia and less freequent in carcinoma than in all other Helicobacter pylori positive patients (2 14.580, df 4, p <0.006). The p 120 (CagA), p 67 (FSH), p 66 (UreB), p 57 (HSP homolog), p 54 (flagelin), p 33, p 30 (OMP), 29 (UreA), p 26, p19, and p17 response was not seen more frequently in Helicobacter pylori patients with peptic ulcer, carcinoma or non ulcer dyspepsia. CONCLUSION: Host response to p95 (VacA) antigen could indicate patients with higher risk for duodenal ulcer and non ulcer dyspepsia outcome but lower risk for carcinoma outcome.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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