Naslov
Eradication of Helicobacter pylori infection with two triple-therapy regimes of 7, 10 and 14 days ; four years experience

Autori
Katičić, Miroslava ; Tićak, Mirjana ; Prskalo, Marija ; Naumovski-Mihalić, Slavica ; Filipec-Kanižaj, Tajana ; Škurla, Bruno ; Šabarić, Branka ; Čolić-Cvrlje, Vesna ; Papa, Branko ;

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Helicobacter / Graham, David, J - Houston (TX) : Wiley-Blackwell, 2006

Skup
The XIXth international workshop on gastrointestinal pathology and Helicobacter.

Mjesto i datum
Wrocław, Poljska, 07.09.2006. - 09.09.2006

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
treatment duration; eradication rate

Sažetak
Aim: The efficacy of Croatian two the most frequently used triple-therapy regimes (Pantoprazole 40 mg, Amoxicillin 1g, Metronidazole 500mg or Clarithromycin 500mg b.d.) of 7, 10, and 14-days duration, was investigated in 596 patients with gastric (GU), duodenal ulcer (DU) and non-ulcer-dyspepsia (NUD), treated from january 2002. till december 2005.yrs. Methods: 172 GU (M/F 100/72), 282 DU (M/F 176/106) and 138 NUD (M/F 59/79), HP-positive patients, underwent endoscopy with histology and culture at the beginning and 4-8 weeks after the end of the treatment. They were randomly assigned to six treatments groups: PAMgroups: A-for 14days(n=58), B-for 10days(n=118), C-for 7days(n=122), PACgroups: D-for 14days(n=58), E-for 10days(n=118), F-for 7days(n=122). 560 patients(94%) completed the study. Results: The results of HP-eradications are presented on Table. Conclusion: In all groups (7, 10, 14 days), the triple-therapy containing clarithromycin had greater HP-eradication rate than that containing metronidazole. The eradication rate exceeding 80% in ITT and 90% in PP calculation, was achieved only by 14-and 10-days of PAC and only by 14-days of PAM. No statistically differences were found among all 6-groups in ulcer-healing-rate, and clinical-improvement-rate was slightly higher in patients with ulcers then in patients with non-ulcer-dyspepsia. (*p<0.05 were found between A- and C-group, and between D- and F-group) Eradication rate(ITT) Eradication rate(PP) A B C 55/58 (95%)* 98/119 (83%) 92/122 (75%)* 55/56 (98%)* 98/109 (90%) 92/113 (81%)* D E F 54/58 (93%)* 93/118 (79%) 90/122 (74%) 54/57 (95%)* 93/112 (83%) 90/113 (80%)*

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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