Pregled bibliografske jedinice broj: 274297
S6-deficiency activates a p53-dependent checkpoint
S6-deficiency activates a p53-dependent checkpoint // Federation of European Cancer Societies
Budimpešta, Mađarska, 2006. (pozvano predavanje, nije recenziran, sažetak, znanstveni)
CROSBI ID: 274297 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
S6-deficiency activates a p53-dependent checkpoint
Autori
Volarević, Siniša
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
Federation of European Cancer Societies
Mjesto i datum
Budimpešta, Mađarska, 30.06.2006. - 03.07.2006
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
ribosome; ribosomal protein S6 gene; mouse embryonic development; p53 protein
Sažetak
Nascent ribosome biogenesis is required during cell growth. To gain insight into importance of this process during mouse oogenesis and embryonic development, we deleted one allele of the ribosomal protein S6 gene in growing oocytes and generated S6-heterozygous embryos. Oogenesis and embryonic development until E5.5 were normal. However, inhibition of entry into M phase of the cell cycle and apoptosis became evident post E5.5, leading to peri-gastrulation lethality. Genetic inactivation of p53 bypassed this checkpoint and prolonged development until E12.5, when they die with defective translation of D-type cyclins and erythropoiesis. Thus, a p53-dependent checkpoint is activated during gastrulation in response to ribosome insufficiency in order to prevent improper execution of the developmental program.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti
