Naslov
Effect Of Water Soluble Derivative Of Propolis And Its Polyphenolic Compounds On Functional Activity Of Macrophages Against Tumor Cells

Autori
Oršolić, Nada ; Bašić, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Apimondia 2005, 39th Apimondia Inernational Apicultural Congress / - , 2005

Skup
Apimondia 2005, 39th Apimondia Inernational Apicultural Congress

Mjesto i datum
Dublin, Irska, 21.08.2005. - 26.08.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Propolis; polyphenolics compounds; macrophage activity; tumor

Sažetak
Effect of two preparation (Croatian and Brazilian) of water-soluble derivative of propolis (WSDP), caffeic acid, quercetin, chrysin, naringenin (components present in WSDP) on the development of Ehrlich ascites tumour (EAT) was evaluated. Test components (50 mg/kg) were given by gastric intubations (po) or intraperitoneally 2 hour prior the intraperitonel injection of EAT (2 x106) cells. It was observed that WSDP and its compounds effectively inhibited tumour growth and the proliferation of EAT. The volume of ascitic fluid induced by EAT cells and total number of cells present in the peritoneal cavity was markedly reduced in EAT-bearing mice treated with test components. Treatment with test components increased the number of polymorphonuclear (PMN) cells and decreased the number of macrophages in the peritoneal cavity of treated animals. The macrophage spreading revealed that WSDP and all test compounds affected the functional state of macrophages increasing their tumorcidal activity. The results indicate that the WSDP and its polyphenolic compounds significantly reduced the tumour growth and proliferation of EAT cells ; the antitumour effect of test components might be due to an increase of peritoneal macrophage activity and not to an increase in macrophage number.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA