Naslov
DMSA in therapy occupational lead poisoning

Autori
Restek-Samaržija, Nada ; Pizent, Alica ; Čorović, Naima ; Zavalić, Marija ; Milković-Kraus, Sanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka / - Zagreb : Hrvatsko toksikološko društvo, 1996

Skup
1. hrvatski toksikološki kongres (s međunarodnim sudjelovanjem) - CROTOX

Mjesto i datum
Zagreb, Hrvatska, 17.04.1996. - 19.04.1996

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
chelation; chronic lead poisoning; dimercaptosuccinic acid (DMSA); occupational exposure

Sažetak
DMSA (2,3-meso dimercaptosuccinic acid) is a new oral chelating agent. Its efficacy was confirmed in the USA, especially in the treatment of children lead poisoning. There are few studies relatedto DMSA chelation in occupationally exposed workers. This study introduces DMSA for the first time in our country with intention to evaluate its efficiency in chronic occupational lead poisoning. Seven workers, employed in a lead battery factory for at least four years, with elevated blood level concentrations (PbB) (>50 ?g/100 ml ) and a positive EDTA lead mobilization test (>600 ?g Pb/24 h urine), were treated with DMSA for 19 days. DMSA was administrated orally in doses of 700 mg DMSA every 8 hours from day 1 to day 5, and 700 mg every 12 hours from day 6 to day 19 of the treatment. Blood lead values declined during the treatment (mean Pb decreased to 15,4% of pretreatment values) with a simultaneous increase in urinary excretion of lead (P<0,01 ). However 15 days after the therapy, PbB values rebounded for 35%, but they did not exceed the treshold level (30 ?g/100 ml). The EDTA lead mobilization test detected a 54% decline of pretreatment values (P<0,01) suggesting a significant reduction of lead in the body. Uor results show that DMSA is an efficient chelating agent for treatment of chronic lead poisonig in occupationally exposed patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA