Naslov
Pyrrole Compounds as Analytical Reagents

Autori
Basarić, Nikola

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Marie Curie Workshop 2006 in Croatia and Serbia Abstract Book / Videnović, Ivan - Beograd : Akademija tehničkih znanosti Hrvatske (HATZ), 2006, 62-62

Skup
Marie Curie Workshop 2006 in Croatia and Serbia Celebrating 150th Anniversary of the birth of Nikola Tesla

Mjesto i datum
Beograd, Srbija; Zagreb, Hrvatska, 07.10.2006. - 11.10.2006

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
anion sensor; calcium; fluorescence indicators; pH; pyrrole

Sažetak
Fluorescent spectroscopy is an attractive technique for measuring concentrations of important ions and molecules [1]. Among biologically important analytes, H+ and Ca2+ have a pivotal role in regulating many processes. Therefore it is of high importance to develop better reagents for these ions. In search for good fluorescent reagents, we turned our attention to compounds composed of pyrrole subunits. Pyrroles are building blocks for biologically important pigments (e.g. heme, chlorophyll), as well as synthetic dyestuffs such as BODIPY. In order to prepare fluorescent sensors for measuring intracellular Ca2+ concentration or pH, BODIPY was functionalized with an APTRA chelating group [2], or phenol moiety [3], respectively. Pyrrole compounds are characterized by the presence of acidic NH protons, which can be used for binding anions. In continuation of our research on the synthesis of chemical sensors, we plan to use pyrroles connected to polycyclic moieties.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA