Naslov
Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives

Autori
Ballian Krznar, Davorka ; Filipović-Grčić, Jelena ; Zorc, Branka ; Zovko, Marijana

Izvornik
Acta Pharmaceutica (1330-0075) 56 (2006), 4; 463-471

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
celecoxib; disks; polyaspartamide; thiomer

Sažetak
A series of mucoadhesive disks with celecoxib as a model drug of very low aqueous solubility were prepared and characterized. Two polymers of polyaspartamide type, poly  ,  -(N-2-hydroxyethyl-DL-aspartamide) (PHEA, 1) and its thiolated analogue poly[α , β -(N-2-hydroxyethyl-DL-aspartamide)]-poly[α , β -(N-2-thioethyl-DL-aspartamide)] copolymer (PHTA, 2a, b), and two commercially available polymers Carbopol 934P and hydroxypropylmethyl cellulose 4000 were used as excipients. Disks containing a mixture of equivalent amounts of thiomer 2b and Carbopol 934P as an excipient exhibited the highest dissolution rate.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA