Naslov
Urinary Bactericidal Activity of Oral Antibiotics against Common Urinary Tract Pathogens in an ex vivo Mode

Autori
Bedenić, Branka ; Topić, Marijana ; Budimir, Ana ; Bubonja, Marina

Izvornik
Chemotherapy (Basel) (0009-3157) 52 (2006); 293-297

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bactericidal activity; urinary beta-Lactam antibiotics
(bactericidal activity; urinary beta -Lactam antibiotics)

Sažetak
In this investigation, the urine samples obtained in a single oral-dose pharmacokinetic study were examined for their bactericidal activity against a range of relevant urinary tract pathogens. Six healthy volunteers received a single oral dose of ten oral antibiotics available in Croatia. Urine samples were taken every 2 h during the whole dosing interval of the particular antibiotic. The urinary bactericidal activity was tested by determination of urinary bactericidal titers. All antibiotics showed a signifi cant urinary bactericidal activity against non-extended spectrum
-lactamase Escherichia coli and Proteus mirabilis . Fluoroquinolones displayed high and persisting levels of urinary bactericidal activity against all gram-negative bacteria and Staphylococcus saprophyticus . Average urinary bactericidal activity can be predicted from in vitro susceptibility testing, but we expect that there will be patients with a low level of urinary bactericidal activity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA