Naslov
Perforin expression in peripheral blood lymphocytes of the pregnant women with multiple sclerosis

Autori
Barac-Latas, Vesna ; Sepčić, Juraj ; Rukavina, Daniel

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Multiple sclerosis Clinical and Laboratory Research / Allen, Ingrid V. - Avenel (NJ) : Stockton press, 1998

Skup
ECTRIMS 98 14th Congress of the European Committee for Treatment and Research in Multiple Sclerosis

Mjesto i datum
Stockholm, Švedska, 09.09.1998. - 12.09.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Perforin; Pregnancy; Multiple sclerosis

Sažetak
Cytotoxic T lymphocytes, CTL, and natural killer, NK, cells contain in their cytoplasmic granules a pore-forming protein, perforin, P, a cytolytic molecule that is a mediator in cell-mediated cytotoxicity, CMC. In unstimulated peripfheral blood lymphocytes, PBL, perforin is constitutively expressed in NK and gamma-delta T cells, high level of expression, and in CD11b+ subpopulation of CD8+ T cells, moderate expression. However P can be induced in the CD8+ CD11b+ subpopulation, as well as in some CD4+ T cells. The aim of the present investigation was to analyse the phenotype and prevalence of perforin-expressing immunocompetent cells in PBL of two patients with clinicaly definite and laboratory supported definite MS during and at the term pregnancy. Perforin and cell surface antigens, CD3, CD4, CD8, CD16 and CD56, were detected simultaneously by flow-cytometry. Upregulation of P expression in the middle of the pregnancy and downregulation at the term pregnancy was found in both MS patients. A significant increase of the percentage of P+ cells was found for total P+ cells and their T-cell subsets, CD4+ P+ and CD8+ P+, in the middle of pregnancy.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA