Pregled bibliografske jedinice broj: 27000
Immunocomplex deposits in the skin of patients with multiple sclerosis
Immunocomplex deposits in the skin of patients with multiple sclerosis // Multiple sclerosis Clinical and Laboratory Research / Allen, Ingrid V. (ur.).
Avenel (NJ): Stockton press, 1998. (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 27000 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Immunocomplex deposits in the skin of patients with multiple sclerosis
Autori
Matijaca, Meri ; Reić, Petar ; Marović, Anton ; Pavelin, Slobodan ; Sepčić, Juraj
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Multiple sclerosis
Clinical and Laboratory Research
/ Allen, Ingrid V. - Avenel (NJ) : Stockton press, 1998
Skup
ECTRIMS 98
14th Congress of the European Committee for Treatment and Research in Multiple Sclerosis
Mjesto i datum
Stockholm, Švedska, 09.09.1998. - 12.09.1998
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
Multiple sclerosis; Immunocomplex; Immunofluorescence-direct
Sažetak
In a group of 72 multiple sclerosis, MS, patients immunocomplex deposits at the dermal-epidermal junction were determined. Our aim was to compare the immunopathologic diagnosis based on a direct immunofluorescence, DIF, with clinical findings in these patients.
Skin biopsy and DIF were performed according to Cormane method which was slighly modified by Gligora. Rabbit anti-human IgG, IgA, IgM and C3 antibodies were used.
The youngest patient was 16 years old and the oldest was 52 years old, showing a female prevalence, 77.8 percent. DIF findings were negative for anti IgG antibodies in 59,7 percent, for anti IgA antibodies in 43 percent, for anti IgM antibodies in 18 percent, for anti C3 antibodies in 78 percent. Fluorescence of granular immunocomplex deposits on the dermal-epidermal junction was positive for anti IgG antibodies in 20,8 percent, for anti IgA antibodies in 50 percent, for anti IgM antibodies in 74 percent, for C3 antibodies in 9,7 percent. Clot forming fluorescence findings were positive for anti IgG antibodies in 15,3 percent, for anti IgA antibodies in 7 percent, for anti IgM antibodies in 8 percent, for anti C3 antibodies in 11 percent. DIF showed positive fluorescence of capillaries for anti IgG antibodies in 2,8 percent and for C3 antibodies in 1,3 percent. DIF showed positive fluorescence of citobodies for anti IgG antibodies in 1,4 percent. Results sugest that the most inportant findings were fluorescence of anti IgM antibodies forming granular immunocomplex deposits.
Izvorni jezik
Engleski
Znanstvena područja
Javno zdravstvo i zdravstvena zaštita
