Naslov
Effect of BMP-2 on leukemic NB-4 cell line

Autori
Topić, Iva ; Marušić, Ana ; Grčević, Danka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / EFIS - Pariz, 2006

Skup
1st Joint Meeting of European National Societies of Immunology Under the auspices of EFIS, 16th European Congress of Immunology - ECI

Mjesto i datum
Pariz, Francuska, 06.09.2006. - 09.09.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
NB4 stanična linija; koštani morfogenetski proteini; diferencijacija
(NB4 cell line; bone morphogenetic proteins; differentiation)

Sažetak
Acute promyelocytic leukemia (APL) is characterized by the clonal expansion of leukemic blasts blocked at the promyelocytic stage of myeloid differentiation. Treatment with all-trans-retinoic acid (ATRA) overcomes this maturation arrest and induces the differentiation of APL progenitors coupled with loss of their replicative potential. The treatment of NB4 cells with ATRA induced myeloid differentiation as evidenced by increased surface expression of CD11b with the major effect 72 hours after treatment. In contrast, BMP-2 did not increase the expression of CD11b when used alone. However, combined treatment with ATRA and BMP-2 significantly blocked the up-regulation of CD11b expression as the marker of myeloid differentiation that was seen in response to ATRA alone

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA