Naslov
Konkomitanatna kemobrahiradioterapija sa ifosfamidom i cisplatinom, praćena konsolidacijskom kemoterapijom u liječenju lokalno uznapredovalog adenokarcinoma ili adenoskvamoznog karcinoma vrata maternice.
(Concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy in the treatment of locally advanced adenocarcinoma or adenosquamous carcinoma of the cervix uteri.)

Autori
Vrdoljak, Eduard ; Boraska Jelavić, Tihana ; Saratlija-Novaković, Zana ; Hamm, Wolfgang

Izvornik
European Journal of Gynaecological Oncology (0392-2936) 26 (2005), 6; 602-4

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
konkomitatna kemobrahiradioterapija; ifosfamid; cisplatina; konsolidacijska kemoterapija; adenokarcinom vrata maternice; adenoskvamozni karcinom vrata maternice
(concomitant chemoradiation; ifosfamide; cisplatin; consolidation chemotherapy; adenocarcinoma of the cervix uteri; adenosquamous carcinoma of the cervix uteri)

Sažetak
The optimal treatment of women with locally advanced adenocarcinoma or adenosquamous carcinoma of the cervix uteri is still undefined. We report a series of four consecutive patients with locally advanced adeno- or adenosquamous carcinomas of the uterine cervix (FIGO Stages IB-IIIB) treated by concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by one to four cycles of consolidation chemotherapy with the same drug combination. After completion of this treatment all patients showed complete clinical remission. Now, after a median follow-up of 40 (range: 13.5-61) months all patients still present with no evidence of disease. Despite the low number of patients in this series we may conclude that concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy with the same drug combination is an efficacious treatment of patients with locally advanced adeno- or adenosquamous carcinomas of the cervix uteri.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA