Naslov
The soluble serum transferin receptors in type 2 diabetic patients with proteinuria

Autori
Šefer, Sinša ; Kes, Petar ; Gaćina, Petar ; Degoricija, Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Bantao Journal 2005 ; 3: (suppl 1) / Balkan Cities Association of Nephrology, Dialysis, Transplantation and Artefitial Organs - Skopje : Macedonian Society of Nephrology, Dialysis, Transplantation and Artefitial Organs, 2005, 13-13

Skup
7th Bantao Congress of the Balkan Cities Association of Nephrology, Dialysis, Transplantation and Arteficial Organs

Mjesto i datum
Ohrid, Sjeverna Makedonija, 08.09.2005. - 11.09.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
type 2 diabetic patient; nephrotic proteinuria; serum soluble transferrine receptors; erythropoesis

Sažetak
To record the difference in the level of soluble serum transferrine receptors (sTfr) in type 2 diabetic patients with selective nephrotic proteinuria (SNP) compared to patients with nonselective nephrotic proteinuria (NNP), and confirm the thesis that the sTfr is good marker of iron status and erythropoesis in these patients. Methods. There were 63 type 2 diabetic patients with diabetic nephropathy and proteinuria included in the study. The patients were divided in to 3 groups regarding largeness and selectivity of proteinuria. Twenty-four patients had SNP, and ninteen patient had NNP. Control group constitute twenty patients with selective non-nephrotic proteinuria <2.5 g/day. In all groups were measured: erythrocyte count, hemoglobin level, mean cell volume, C reactive protein, fibrinogen level, serum iron level, total iron binding capacity, unbound iron binding capacity, iron saturation, serum ferritin, cratinine clearance, serum protein electrophoresis, proteinuria (biuret), urinary protein immunoelectrophoresis, and sTfr. The sTfr were detected in serum using ELISA techniques, and quantified in mg/L. Results. We recorded significant difference in sTfr level between NNP group and SNP group, and between NNP group and control group (NNP 2.0+/-0.8 ; SNP 2.9+/-1.8 ; control 2.7+/-1.0 ; p<0.05 ; p<0.05), and significant difference in biuret and fibrinogen level between NNP and SNP group in compare to control group (p<0.05 ; p<0.05). Conclusion. Significantly lower sTfr in NNP group in compare to SNP and controle group, and in absence of significant difference in both iron and erythropoesis markers and factors with possible negative contribution according to both of them (e.g. inflammation, stage of renal insufficiency), is probably result of loss of sTfr through heavily and largely damaged glomerular capillary membrane in NNP group. Therefore, sTfr is not good marker of iron status and erythropoesis in type 2 diabetic patients with NNP.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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