Naslov
TNF-alpha promoter SNPs in gastroenteropancreatic neuroendocrine tumors (GEP-NET)

Autori
Berković, Maja ; Čačev, Tamara ; Zjačić-Rotkvić, Vanja ; Kapitanović, Sanja

Izvornik
Neuroendocrinology (0028-3835) 84 (2006), 5; 346-352

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
neuroendocrine tumors; tumor necrosis factor alpha; polymorphism

Sažetak
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) secrete biogenic amines, hormones and growth factors, among which tumor necrosis factor alpha (TNF-alpha). As the expression of TNF-alpha is mostly regulated at the transcriptional level, its promoter polymorphisms have been intensively studied as a potential determinant of TNF-alpha production and cancer susceptibility. We have analyzed for the first time the potential association between -238, -308, -857 and -1031 TNF-alpha promoter polymorphisms and GEP-NETs. The study included 65 individuals diagnosed with GEP-NET and 154 healthy age and sex matched controls. Although most of the patients had solitary GEP-NETs, six were diagnosed with GEP-NET as a part of multiple endocrine neoplasia type 1 (MEN-1) and one as a part of neurofibromatosis type 1 (NF-1). The C allele at the -1031 position was more frequent in GEP-NET patients (p<0.0005) suggesting its possible role in GEP-NET development. The significant difference between forgut and midgut GEP-NET patients was observed in the -308 high expression genotypes and -308A allele (high expression) which tend to occur more frequently in the forgut GEP-NETs (p=0.0392 and p=0.0350 respectively). When functional and non-functional PETs were compared there were no significant differences in the researched TNF-alpha SNPs. The results suggest the putative role of TNF-alpha -1031 polymorphism in the development of GEP-NET.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA