Naslov
The functional design of the rotary enzyme ATP synthase is consistent with maximum entropy production

Autori
Dewar, Roderick ; Juretić, Davor ; Županović, Paško

Izvornik
Chemical Physics Letters (0009-2614) 430 (2006); 177-182

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
proizvodnja entropije; ATP sintaza; Shannonova entropija
(entropy production; ATP synthase; Shannon entropy)

Sažetak
We show that the molecular motor ATP synthase has evolved in accordance with the statistical selection principle of Maximum Shannon Entropy and one of its corollaries, Maximum Entropy Production. These principles predict an optimal angular position for the ATP-binding transition close to the experimental value ; an inverse relation between the optimal gearing ratio and the proton motive force (pmf) ; optimal operation at an inflection point in the curve of ATP synthesis rate versus pmf, enabling rapid metabolic control ; and a high optimal free energy conversion efficiency. Our results suggest a statistical interpretation for the evolutionary optimization of ATP synthase function.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija

POVEZANOST RADA