Pregled bibliografske jedinice broj: 265427
Ekspresija BMP-7 u upalnim bolestima bubrega
Ekspresija BMP-7 u upalnim bolestima bubrega // 4th Urological Alpe-Adria Meeteng, Graz ; 2006 ; Abstract book / Petrich, Karl (ur.).
Graz: Clinic of Urology, University of Graz, 2006. str. 3-3 (predavanje, nije recenziran, sažetak, znanstveni)
CROSBI ID: 265427 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Ekspresija BMP-7 u upalnim bolestima bubrega
(BMP-7 expression in renal inflamatory diseases)
Autori
Španjol, Josip ; Markić, Dean ; Sotošek, Stanislav ; Fučkar, Željko ; Bobinac, Dragica
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
4th Urological Alpe-Adria Meeteng, Graz ; 2006 ; Abstract book
/ Petrich, Karl - Graz : Clinic of Urology, University of Graz, 2006, 3-3
Skup
4th Urological Alpe-Adria Meeteng, Graz ; 2006
Mjesto i datum
Graz, Austrija, 15.09.2006. - 16.09.2006
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
BMP-7 expression; Pyelonephritis; Renal fibrosis
Sažetak
Bone morphogenetic protein 7 (BMP 7) is a member of the transforming growth factor (TGF) beta superfamily and is involved in regeneration, repair, and development of specific tissues, for example kidney and skeleton. The experimental studies have shown its protective role against fibrotic processes. Tubulointerstitial changes are present in the pyelonephritic kidney which progresses to fibrosis. Renal fibrosis may lead to the loss of renal function. The aim of this study was to investigate BMP 7 expression in acute and chronic pyelonephritis in humans. 3 patients with acute pyelonephritis and 7 with chronic pyelonephritis were treated in Department of Nephrology Clinical Hospital, Rijeka. Tissue biopsy was taken and renal tissue was studied histopathologically by use of hematoxylin and eosin and scored for diagnosis of pyelonephritis. BMP 7 expression was studied by Imunohistochemical staining. BMP 7 expression was observed in the tubular area of the pyelonephritic kidneys. The expression of BMP7 was stronger in the acute pyelonephritic group and more less in the chronic pyelonephritic group of patients. The results imply that BMP 7 has a role in chronic pyelonephritis. Tubular BMP 7 expression had a negative correlation with fibrosis and tubular, atrophy. Our results are suggesting that BMP-7 plays an important protective role in renal inflammatory diseases preventing greater damage and fibrosis.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
