Naslov
Correlation of 25(OH) and 1, 25(OH)2 vitamin D serum levels and development of benign prostate hyperplasia and prostate cancer

Autori
Galić, Josip ; Šimunović, Dalibor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the EAU 6th Central European Meeting / - Prag, 2006

Skup
EAU 6th Central European Meeting

Mjesto i datum
Prag, Češka Republika, 15.09.2006. - 16.09.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
prostate cancer; vitamin D; development. epidemiology

Sažetak
Inhibitory role of vitamin D has been recognized in development and progression of prostate cancer. Vitamin D inhibits cellular proliferation in some prostate cancer cell lines by mechanism of cell cycle arrest, or altering activation of growth factor signals and by inducing apoptosis (1, 2, 3, 4). A lower levels of vitamin D have been correlated, by some studies, with higher risk of developing prostate cancer, especially in younger men with lower 25(OH) vitamin D levels (5, 6). Some suggestions have been made to include measurements of 25(OH) vitamin D serum levels in men at regular exams or at least in screening purposes to help predict risk of prostate cancer development (7). In this study we analyzed if there is significant difference in serum levels of 25(OH) vitamin D and 1, 25(OH)2 vitamin D in subjects with benign prostate hyperplasia or prostate cancer within our test population. We have found a significantly lower levels of 25(OH) vitamin D in our subjects with prostate cancer or benign prostate hyperplasia when compared with healthy patients. This result correlates with, by some, proposed thesis that lower levels of vitamin D increase risk of prostate cancer. Vitamin D is known to inhibit cellular proliferation, so lower levels could be expected to be found in BPH since a cellular hyperplasia is primary mechanism of prostate enlargement. Overall findings on our randomly selected population could be confirmatory to thesis that a decreased vitamin D levels are correlated with higher risk of prostate cancer development. Although a several conducted studies shown a controversial clinical importance and benefits in simple vitamin D serum levels measurements our results have clearly shown that serum levels of 25(OH) vitamin D are significantly lower in subjects with BPH or prostate cancer.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
European Urology (ISSN 1872-7174) 1 (2006) (1) 131- 131

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