Naslov
Novi koncept testikularne ekstrakcije sjemena (TESE) - korelacija izmedju morfologije testisa, rezultata TESE-a, analize sjemena i vrijednosti hormona u serumu 103 neplodna muskarca
(THE NEW CONCEPT FOR TESTICULAR SPERM EXTRACTION (TESE) - CORRELATION BETWEEN TESTICULAR MORPHOLOGY, TESE RESULTS, SEMEN ANALYSIS AND SERUM HORMONE VALUES IN 103 INFERTILE MEN)

Autori
Ježek, Davor ; Schulze, Wolfgang

Izvornik
HDGO

Vrsta, podvrsta
Ostale vrste radova, ostalo

Godina
1998

Sažetak
THE NEW CONCEPT FOR TESTICULAR SPERM EXTRACTION (TESE) - CORRELATION BETWEEN TESTICULAR MORPHOLOGY, TESE RESULTS, SEMEN ANALYSIS AND SERUM HORMONE VALUES IN 103 INFERTILE MEN Davor Ježek and Wolfgang Schulze* Institute of Histology and Embryology, Medical Faculty University of Zagreb, Croatia *Department of Andrology, University of Hamburg, Germany Spermatozoa recovered from testicular biopsies can be used through intracytoplasmic sperm injection (ICSI) to achieve a pregnancy. To assess the likelihood of successful testicular sperm extraction (TESE) in men suffering from severe oligo- or azoospermia, bilateral biopsy specimens were obtained. Following semi-thin sectioning, the morphology of testicular samples was graded according to a modified Johnsen score. TESE was performed in parallel to this histological examination. The number of isolated spermatozoa was assessed in a semiquantitative way. From 103 patients investigated, 64 (62.1%) showed azoospermia in a preceding semen analysis and 29 (28.2%) patients had sperm concentrations between 0.1 and 1x106/ml. In 10 patients who had higher sperm counts, most spermatozoa were non-motile. Spermatozoa could be detected after TESE in the testicular tissue of 49 (77%) azoospermic men. When follicle stimulating hormone (FSH) concentration was normal, most patients had detectable spermatozoa after TESE. Nearly one-third of patients with mildly elevated FSH had no spermatozoa. Thirty-nine percent of patients in whom FSH was elevated to more than twice normal and 50% of patients with grossly elevated FSH had no detectable spermatozoa. In all, 82.8% of men with sperm concentrations between 0.1 and 1x106/ml in their ejaculate showed spermatozoa in the tissue sample after TESE. Our data demonstrate that, contrary to previous recommendations, infertile men with azoospermia and high FSH values should be reconsidered for testicular biopsy, provided that tissue samples can be cryopreserved for later TESE/ICSI treatment.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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