Naslov
Hepatitis C: who should be treated?

Autori
Štimac, Davor ; Milić, Sandra

Izvornik
Acta Medica Croatica (1330-0164) 59 (2005), 5; 423-427

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
hepatitis C; treatment

Sažetak
The goals of treatment for hepatitis C are eradication of viral infection and prevention of progression to end-stage liver disease. To decide on whom to treat, it is necessary to consider the following parameters: stage of disease, comorbidity, patient age, probability of therapeutic success, contraindications, and therapy associated risks. Therapy is recommended in patients with elevated ALT levels, patients with normal ALT level and at least F2 METAVIR score, nonresponders to standard interferon monotherapy, patients with compensated liver cirrhosis, and patients with acute infection. It is possible to treat patients with HBV and HIV co-infection, patients with severe extrahepatic manifestations of HCV infection, and patients with transplanted liver. Drug users and alcoholics can be treated after 12-month abstinence. Therapy is not recommended in patients with fulminant hepatitis, patients with persistently normal ALT levels without fibrosis, kidney transplant recipients, and pregnant women.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA