Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 263920

Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes

Yusuf, S.; Mehta, S.R.; Bassand, J.P.; Budaj, A.; Chrolavicius, S.; Fox, K.A.A.; Granger, C.B.; Joyner, C.; Peters, R.J.G.; Wallentin, L. et al.
Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes // The New England Journal of Medicine, 354 (2006), 14; 1464-1476 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 263920 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes

Autori
Yusuf, S. ; Mehta, S.R. ; Bassand, J.P. ; Budaj, A. ; Chrolavicius, S. ; Fox, K.A.A. ; Granger, C.B. ; Joyner, C. ; Peters, R.J.G. ; Wallentin, L. ; Avezum, A. ; Boden, W. ; Cardona, E. ; Ceremuzynski, L. ; Col, J. ; Commerford, P.J. ; Diaz, R. ; Faxon, D. ; Flather, M. ; Fodor, G. ; Franzosi, M.G. ; Granger, C. ; Halon, D. ; Hunt, D. ; Karatzas, N. ; Keltai, M. ; Kenda, M. ; Kim, J.H. ; Lanas, F. ; Lau, C.P. ; Lewis, B.S. ; Morais, J. ; Moccetti, T. ; Pais, P. ; Paolasso, E. ; Parkhomenko, A. ; Petrauskiene, B. ; Piegas, L. ; Pipilis, A. ; Robaayah, D. ; Ruda, M. ; Rumboldt, Zoran ; Rupprecht, H.J. ; Sitkei, E. ; Steg, P.G. ; Swahn, E. ; Theroux, P. ; Valentin, V. ; Varigos, J. ; Weitz, J. ; White, H. ; Widimsky, P. ; Xavier, D. ; Zhu, J.R. ; Ameriso, S. ; Bonilla, C. ; Braekken, S. ; Chan, Y.K. ; Chen, W. ; Chenniappan, M. ; Cohen, E. ; Cottin, Y. ; Csiba, L. ; Czepiel, A. ; de Raedt, H. ; Finet, G. ; Gardinale, E. ; Gaxiola, E. ; Gorecki, A. ; Gregor, P. ; Happola, O. ; Heras, M. ; Himbert, D. ; Irkin, O. ; Isaaz, K. ; Iyengar, S.S. ; Kalvach, P. ; Kevers, L. ; Klosiewicz-Wasek , B. ; Laine, M. ; Leys, D. ; Lundstrom, E. ; Lušić, Ivo ; Lutay, Y. ; Maggioni, A. ; Massaro, A. ; Mayosi, B.M. ; Moulin, T. ; Narendra, J. ; Naslund, U. ; Peeters, A. ; Penicka, M. ; Perakis, A. ; Petersen, P. ; Polić, S. ; Radhakrishnan, S. ; Renkin, J. ; Stockins, B. ; Sundararajan, R. ; Thygesen, K. ; Turazza, F. ; van Belle, E. ; Vik-Mo, H. ; Zaborski, J. ; Sleight, P. ; Anderson , J.L. ; Johnstone D. ; Hirsh, J. ; de Mets, D. ; Holmes, D.R. ; Meeks, B. ; Afzal, R. ; Pogue, J. ; Boccalon, S. ; Chrysler, K. ; Cracknell, B. ; Horsman, C. ; Hoskin, T. ; Jedrzejowski. B. ; Johnson, J. ; Kotlan, S. ; Lawrence, M. ; Smiley, M. ; Stevens, C. ; Yallup, R. ; Connolly, S. ; Demers, C. ; Devereaux, P.J. ; Healey, J. ; Lonn, E. ; Magloire, P. ; McKelvie, R. ; Morillo, C. ; Natarajan, M. ; Rokoss, M. ; Teo, K. ; Valettas, N. ; Velianou, J. ; Bakula, Miro ; Bergovec, M ; Lukin Ajvor ; Miličević, Goran ; Padovan, Milko ; Polić, S. ; Raguž, M. ; et al.

Izvornik
The New England Journal of Medicine (0028-4793) 354 (2006), 14; 1464-1476

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ST-segment elevation; high-risk patients; unfractionated heparin; myocardial infarction; collaborative metaanalysis; randomized trials; initial treatment; american-college; task-force; prevention

Sažetak
The combined use of anticoagulants, antiplatelet agents, and invasive coronary procedures reduces ischemic coronary events but also increases bleeding in patients with acute coronary syndromes. We therefore assessed whether fondaparinux would preserve the anti-ischemic benefits of enoxaparin while reducing bleeding. We randomly assigned 20, 078 patients with acute coronary syndromes to receive either fondaparinux (2.5 mg daily) or enoxaparin (1 mg per kilogram of body weight twice daily) for a mean of six days and evaluated death, myocardial infarction, or refractory ischemia at nine days (the primary outcome) ; major bleeding ; and their combination. Patients were followed for up to six months. The number of patients with primary-outcome events was similar in the two groups (579 with fondaparinux [5.8 percent] vs. 573 with enoxaparin [5.7 percent] ; hazard ratio in the fondaparinux group, 1.01 ; 95 percent confidence interval, 0.90 to 1.13), satisfying the noninferiority criteria. The number of events meeting this combined outcome showed a nonsignificant trend toward a lower value in the fondaparinux group at 30 days (805 vs. 864, P=0.13) and at the end of the study (1222 vs. 1308, P=0.06). The rate of major bleeding at nine days was markedly lower with fondaparinux than with enoxaparin (217 events [2.2 percent] vs. 412 events [4.1 percent] ; hazard ratio, 0.52 ; P<0.001). The composite of the primary outcome and major bleeding at nine days favored fondaparinux (737 events [7.3 percent] vs. 905 events [9.0 percent] ; hazard ratio, 0.81 ; P<0.001). Fondaparinux was associated with a significantly reduced number of deaths at 30 days (295 vs. 352, P=0.02) and at 180 days (574 vs. 638, P=0.05). Fondaparinux is similar to enoxaparin in reducing the risk of ischemic events at nine days, but it substantially reduces major bleeding and improves long term mortality and morbidity. (ClinicalTrials.gov number, NCT00139815 [ClinicalTrials.gov] .)

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
0219163
0141011

Ustanove:
Medicinski fakultet, Osijek

Profili:

Avatar Url Ajvor Lukin (autor)

Avatar Url Zoran Rumboldt (autor)

Avatar Url Milko Padovan (autor)

Avatar Url Ivo Lušić (autor)

Citiraj ovu publikaciju:

Yusuf, S.; Mehta, S.R.; Bassand, J.P.; Budaj, A.; Chrolavicius, S.; Fox, K.A.A.; Granger, C.B.; Joyner, C.; Peters, R.J.G.; Wallentin, L. et al.
Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes // The New England Journal of Medicine, 354 (2006), 14; 1464-1476 (međunarodna recenzija, članak, znanstveni)
Yusuf, S., Mehta, S., Bassand, J., Budaj, A., Chrolavicius, S., Fox, K., Granger, C., Joyner, C., Peters, R. & Wallentin, L. (2006) Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes. The New England Journal of Medicine, 354 (14), 1464-1476.
@article{article, author = {Yusuf, S. and Mehta, S.R. and Bassand, J.P. and Budaj, A. and Chrolavicius, S. and Fox, K.A.A. and Granger, C.B. and Joyner, C. and Peters, R.J.G. and Wallentin, L. and Avezum, A. and Boden, W. and Cardona, E. and Ceremuzynski, L. and Col, J. and Commerford, P.J. and Diaz, R. and Faxon, D. and Flather, M. and Fodor, G. and Franzosi, M.G. and Granger, C. and Halon, D. and Hunt, D. and Karatzas, N. and Keltai, M. and Kenda, M. and Kim, J.H. and Lanas, F. and Lau, C.P. and Lewis, B.S. and Morais, J. and Moccetti, T. and Pais, P. and Paolasso, E. and Parkhomenko, A. and Petrauskiene, B. and Piegas, L. and Pipilis, A. and Robaayah, D. and Ruda, M. and Rumboldt, Zoran and Rupprecht, H.J. and Sitkei, E. and Steg, P.G. and Swahn, E. and Theroux, P. and Valentin, V. and Varigos, J. and Weitz, J. and White, H. and Widimsky, P. and Xavier, D. and Zhu, J.R. and Ameriso, S. and Bonilla, C. and Braekken, S. and Chan, Y.K. and Chen, W. and Chenniappan, M. and Cohen, E. and Cottin, Y. and Csiba, L. and Czepiel, A. and de Raedt, H. and Finet, G. and Gardinale, E. and Gaxiola, E. and Gorecki, A. and Gregor, P. and Happola, O. and Heras, M. and Himbert, D. and Irkin, O. and Isaaz, K. and Iyengar, S.S. and Kalvach, P. and Kevers, L. and Klosiewicz-Wasek, B. and Laine, M. and Leys, D. and Lundstrom, E. and Lu\v{s}i\'{c}, Ivo and Lutay, Y. and Maggioni, A. and Massaro, A. and Mayosi, B.M. and Moulin, T. and Narendra, J. and Naslund, U. and Peeters, A. and Penicka, M. and Perakis, A. and Petersen, P. and Poli\'{c}, S. and Radhakrishnan, S. and Renkin, J. and Stockins, B. and Sundararajan, R. and Thygesen, K. and Turazza, F. and van Belle, E. and Vik-Mo, H. and Zaborski, J. and Sleight, P. and Anderson, J.L. and Hirsh, J. and de Mets, D. and Holmes, D.R. and Meeks, B. and Afzal, R. and Pogue, J. and Boccalon, S. and Chrysler, K. and Cracknell, B. and Horsman, C. and Hoskin, T. and Johnson, J. and Kotlan, S. and Lawrence, M. and Smiley, M. and Stevens, C. and Yallup, R. and Connolly, S. and Demers, C. and Devereaux, P.J. and Healey, J. and Lonn, E. and Magloire, P. and McKelvie, R. and Morillo, C. and Natarajan, M. and Rokoss, M. and Teo, K. and Valettas, N. and Velianou, J. and Bakula, Miro and Bergovec, M and Mili\v{c}evi\'{c}, Goran and Padovan, Milko and Poli\'{c}, S. and Ragu\v{z}, M.}, year = {2006}, pages = {1464-1476}, keywords = {ST-segment elevation, high-risk patients, unfractionated heparin, myocardial infarction, collaborative metaanalysis, randomized trials, initial treatment, american-college, task-force, prevention}, journal = {The New England Journal of Medicine}, volume = {354}, number = {14}, issn = {0028-4793}, title = {Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes}, keyword = {ST-segment elevation, high-risk patients, unfractionated heparin, myocardial infarction, collaborative metaanalysis, randomized trials, initial treatment, american-college, task-force, prevention} }
@article{article, author = {Yusuf, S. and Mehta, S.R. and Bassand, J.P. and Budaj, A. and Chrolavicius, S. and Fox, K.A.A. and Granger, C.B. and Joyner, C. and Peters, R.J.G. and Wallentin, L. and Avezum, A. and Boden, W. and Cardona, E. and Ceremuzynski, L. and Col, J. and Commerford, P.J. and Diaz, R. and Faxon, D. and Flather, M. and Fodor, G. and Franzosi, M.G. and Granger, C. and Halon, D. and Hunt, D. and Karatzas, N. and Keltai, M. and Kenda, M. and Kim, J.H. and Lanas, F. and Lau, C.P. and Lewis, B.S. and Morais, J. and Moccetti, T. and Pais, P. and Paolasso, E. and Parkhomenko, A. and Petrauskiene, B. and Piegas, L. and Pipilis, A. and Robaayah, D. and Ruda, M. and Rumboldt, Zoran and Rupprecht, H.J. and Sitkei, E. and Steg, P.G. and Swahn, E. and Theroux, P. and Valentin, V. and Varigos, J. and Weitz, J. and White, H. and Widimsky, P. and Xavier, D. and Zhu, J.R. and Ameriso, S. and Bonilla, C. and Braekken, S. and Chan, Y.K. and Chen, W. and Chenniappan, M. and Cohen, E. and Cottin, Y. and Csiba, L. and Czepiel, A. and de Raedt, H. and Finet, G. and Gardinale, E. and Gaxiola, E. and Gorecki, A. and Gregor, P. and Happola, O. and Heras, M. and Himbert, D. and Irkin, O. and Isaaz, K. and Iyengar, S.S. and Kalvach, P. and Kevers, L. and Klosiewicz-Wasek, B. and Laine, M. and Leys, D. and Lundstrom, E. and Lu\v{s}i\'{c}, Ivo and Lutay, Y. and Maggioni, A. and Massaro, A. and Mayosi, B.M. and Moulin, T. and Narendra, J. and Naslund, U. and Peeters, A. and Penicka, M. and Perakis, A. and Petersen, P. and Poli\'{c}, S. and Radhakrishnan, S. and Renkin, J. and Stockins, B. and Sundararajan, R. and Thygesen, K. and Turazza, F. and van Belle, E. and Vik-Mo, H. and Zaborski, J. and Sleight, P. and Anderson, J.L. and Hirsh, J. and de Mets, D. and Holmes, D.R. and Meeks, B. and Afzal, R. and Pogue, J. and Boccalon, S. and Chrysler, K. and Cracknell, B. and Horsman, C. and Hoskin, T. and Johnson, J. and Kotlan, S. and Lawrence, M. and Smiley, M. and Stevens, C. and Yallup, R. and Connolly, S. and Demers, C. and Devereaux, P.J. and Healey, J. and Lonn, E. and Magloire, P. and McKelvie, R. and Morillo, C. and Natarajan, M. and Rokoss, M. and Teo, K. and Valettas, N. and Velianou, J. and Bakula, Miro and Bergovec, M and Mili\v{c}evi\'{c}, Goran and Padovan, Milko and Poli\'{c}, S. and Ragu\v{z}, M.}, year = {2006}, pages = {1464-1476}, keywords = {ST-segment elevation, high-risk patients, unfractionated heparin, myocardial infarction, collaborative metaanalysis, randomized trials, initial treatment, american-college, task-force, prevention}, journal = {The New England Journal of Medicine}, volume = {354}, number = {14}, issn = {0028-4793}, title = {Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes}, keyword = {ST-segment elevation, high-risk patients, unfractionated heparin, myocardial infarction, collaborative metaanalysis, randomized trials, initial treatment, american-college, task-force, prevention} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • Excerpta Medica
  • Index Medicus

Podijeli:





Contrast
Increase Font
Decrease Font
Dyslexic Font
CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.