Naslov
Crystal structure study of two (E)-(4-phthalimido- 2-buten-1-yl) pyrimidine derivatives

Autori
Cetina, Mario ; Mrvoš-Sermek, Draginja ; Nagl, Ante ; Krištafor, Vedran ; Mintas, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Fifteenth Slovenian-Croatian Crystallographic Meeting / Lah, Nina ; Leban, Ivan - Ljubljana : Fakulteta za kemijo in kemijsko tehnologijo Univerze v Ljubljani, 2006, 44-44

Skup
Fifteenth Slovenian-Croatian Crystallographic Meeting

Mjesto i datum
Jezersko, Slovenija, 15.06.2006. - 18.06.2006

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
pyrimidine derivatives ; supramolecular assembling ; hydrogen bonds

Sažetak
Nucleoside analogues have been shown as potential antiviral agents, especially those that have a rigid structural element, e.g. a double bond into nucleoside or carbocyclic nucleoside structure. Herein we describe the crystal structures of two (E)-(4-phthalimido-2- buten-1-yl) pyrimidine derivatives: (E)-1-(4- phthalimido-2-buten-1-yl)uracil (1) and (E)-1- (4-phthalimido-2-buten-1-yl)-5-fluorouracil (2). The molecules of 1 are joined by one hydrogen bond of N-H...O type, thus forming centrosymmetric dimmers via eight-membered rings. The action of this hydrogen bond is reinforced by two C-H...O hydrogen bonds that link the dimmers into three-dimensional network. In 2, the N-H...O hydrogen bond also form centrosymmetric dimmers via eight-membered rings. The dimmers are additionally linked by two C-H...O hydrogen bonds and one C-H...F hydrogen bond, so forming two-dimensional network.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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