Naslov
Facts about nicotine toxicity

Autori
Brčić Karačonji, Irena

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 56 (2005), 4; 363-371

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
acute toxicity; exposure; long-term toxicity; NOAEL; risk estimation; risk evaluation

Sažetak
Nicotine is an alkaloid obtained from the leaves of the tobacco plant and it is the main constituent of tobacco smoke. This review opens with physical and chemical properties of nicotine and with general considerations about the methods for determining nicotine and its metabolite cotinine. It summarises the data about acute and long-term toxicity of nicotine andr also reviews its metabolism and kinetic data, types of exposure and the main recognised health effects, with special attention to reproductive, cardiovascular, pulmonary, gastrointestinal, immunological and genetic toxicity. The main focus is on hazardous exposure and risk estimation.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA