Pregled bibliografske jedinice broj: 262452
Direct antitumor activity of honey bee venom in vitro and in vivo.
Direct antitumor activity of honey bee venom in vitro and in vivo. // 9. Hrvatski biološki kongres / Višnja Besendorfer, Goran I.V. Klobučar (ur.).
Rovinj, 2006. str. 253-255 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 262452 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Direct antitumor activity of honey bee venom in vitro and in vivo.
Autori
Oršolić, Nada ; Bašić, Ivan
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
9. Hrvatski biološki kongres
/ Višnja Besendorfer, Goran I.V. Klobučar - Rovinj, 2006, 253-255
Skup
9. Hrvatski biološki kongres
Mjesto i datum
Rovinj, Hrvatska, 24.03.2006. - 29.03.2006
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
bee venom; antitumor activity; mice; cell culture
Sažetak
In our previous study we demonstrated that antitumour and antimetastatic effects of bee venom could be highly dependent on route of injection and on close contact between bee venom and tumour cells. Here we were particularly interested in antitumour activities of bee venom given intratumourally at different times after tumour cell inoculation and in clarification of the mechanisms by which bee venom produced these effects. Tumor was a transplantable mammary carcinoma (MCa) of spontaneous origin. Tumor in footpad was generated by sc injection of 1 x 105 tumor cells. In in vitro studies we used HeLa and MCa cells. Groups of 7 mice bearing mammary carcinoma tumors were treated with single injection of bee venom subcutaneously (sc) at doses of 150, 300, 600  g/mouse after 7 and/or 14 days and effectiveness of bee venom on tumour growth was determined as tumour-growth inhibition rate (TIR%). When bee venom was injected intratumourally tumours decreased in size ; some sort of shrinkage of tumours occurred, and the delay of tumour growth was evident. Survival of bee venom treated mice was prolonged compared to control mice. Bee venom significantly inhibited tumour growth ; tumour inhibition effect of bee venom was dose- and time depedent in vivo and in vitro as shown by studies with HeLa and MCa cells. In summary, this study together with previous one demonstrate that apoptosis, necrosis and lysis of tumor cells could be the possible mechanisms by which bee venom inhibited tumor growth. Furthermore, it is likely that more attention should be paid to natural inhibitor of tumor growth such as bee venom and other products of bee hive in testing their antitumor activity for future possible use in clinical practice.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Ustanove:
Hrvatski veterinarski institut, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb
