Naslov
Angiogenesis in Gastric Cancer

Autori
Kovač, Dražen ; Valković, Toni ; Ivaniš, Nikola ; Rubinić, Milivoj ; Inferrera, Cosimo ; Caruso, R. ; Melato, Mauro ; Jonjić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
3rd International Gastric Cancer Congress

Mjesto i datum
Seoul, Republika Koreja, 27.04.1999. - 30.04.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
angiogenesis; gastric cancer

Sažetak
This study aimed to compare the bilogy of gastric cancers in their early and advanced stages. As a basis for comparison we evaluated the extent of neovascularisation in the tumor. The microvessel quantitation in gastric cancer was analysed in a study group that included 20 patients with "early" and 29 patients with "advanced" gastric carcinomas.Small blood vessels were visualized by staining endothelial cells for Von Willebrand Factor (DAKO) using a standard immunoperoxidase ABC-technique on parafin-embedded sections. The three most vascular areas ("hot spots") were identified on each slide.Microvessel were counted at magnification x200. The average count from the three hot spots and the highest single field count were recorded for subseqent statistical analysis. "Early" gastric cancer demonstrated significantly higher microvessel count than advanced cancer (p=0,0088). Also, younger patients showed significantly higher average count than older patients (p=0,029). There were no significant differences between parameters of neovascularisation and sex or histological type of tumor. This preliminar investigation indicates the biological differences between "early" and "advanced" gastric cancer.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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