Naslov
Serum and intestinal dipeptidyl peptidase IV (DPP IV/CD26) activity in children with celiac disease

Autori
Detel, Dijana ; Peršić, Mladen ; Batičić, Lara ; Varljen, Jadranka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology / Kovarik, Zrinka - Zagreb : Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2006

Skup
Congress of the Croatian Society of Biochemistry and Molecular Biology

Mjesto i datum
Vodice, Hrvatska, 03.10.2006. - 07.10.2006

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Dipeptidyl peptidase IV (DPP IV/CD26); Celiac disease; Malabsorption syndrome; Children

Sažetak
The serine-protease dipeptidyl peptidase IV (DPP IV/CD26) is involved in the degradation of prolin-rich proteins such as gliadin and in the modulation of the immune response. The celiac disease is an immune-mediated entheropathy, triggered by the ingestion of gluten and/or related cereal proteins in genetically predisposed individuals. The aim of this study was to determine the serum and intestinal DPP IV enzyme activity in children with celiac disease in order to evaluate their possible causal connection. The study was performed on 145 patients with malabsorption syndrome and 50 patients without gastrointestinal diseases. Intestinal mucosal biopsies for the DPP IV enzyme activity determination were taken from 97 patients with malabsorption syndrome. Blood samples for DPP IV enzyme activity analysis were collected from 48 patients with active celiac disease and 50 patients without gastrointestinal diseases, which represented the control group. The DPP IV activity in the small intestine correlated inversely with the grade of mucosal damage degree in patients with celiac disease (r=-0, 88 ; P<0, 001) and malabsorption syndrome of other etiology (r=-0, 83 ; P<0, 001). Intestinal DPP IV activity was statistically significantly decreased in all three groups of patients with celiac disease compared to the control group (P<0, 05). On the other hand, no statistically significant differences in the serum DPP IV activity between patients with celiac disease and the control group were found. The results obtained in our study suggest that the DPP IV could not be involved in the pathogenesis of the celiac disease. Our data also indicate that the determination of the serum DPP IV activity could not be used as a specific non-invasive diagnostic or prognostic marker of the disease.

Izvorni jezik
Engleski

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