Naslov
Changes in serum lipid and lipoprotein levels in postmenopausal patients with node-positive breast cancer treated with tamoxifen

Autori
Vrbanec, Damir ; Reiner, Željko ; Belev, Boris ; Pleština, Stjepko

Izvornik
Tumori (0300-8916) 84 (1998), 6; 687-690

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adjuvant therapy; breast cancer; lipid; lipoprotein;tamoxifen
(adjuvant therapy; breast cancer; lipid; lipoprotein; tamoxifen)

Sažetak
Tamoxifen has benn used for a long time as an adjuvant hormonal treatment in breast cancer patients. We studied 62 newly diagnosed postmenopausal women, aged 50-79 years, with node positive breast cancer and receiving adjuvant tamoxifen (20 mg per day). Total serum cholesterol, tryglicerides, HDL-cholesterol, LDL-cholestrol, VLDL-cholesterol, apo AI, apo AII, apo B and Lp(a) were determined before the surgery and 3,6,9,12 and 24 months after starting tamoxifen treatment. Tamoxifen significantly reduced total serum cholesterol (6.13+/-1.20 mmol/L vs 5.21+/-1.05 mmmol/L)(P<0.01), LDL-cholesterol (3.72+/-0.70 mmol/L vs 2.93+/-0.51)(p<0.01) and Lp(a)(0.11+/-0.70 g/L vs 0.02+/-0.01g/L)(p<0.01).There were no changes in triglycerides or HDL-cholesterol serum levels during tamoxifen treatment. These results indicate that an additional beneficial effect of adjubant tamoxifen therapy may be that it decreases cardiovascular risk in such patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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