Naslov
Effect of Thiomersal and mercuric chloride on mercury distribution in suckling rats

Autori
Orct, Tatjana ; Lazarus, Maja ; Blanuša, Maja ; Kostial, Krista

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the EUROTOX 2006/6 CTDC Congress. Toxicology Letters 164S / Kniewald, Jasna - Amsterdam : Boston : Jena : London : Elsevier, 2006, S191-S192

Skup
43rd Congress of the European Societies of Toxicology & 6th Congress of Toxicology in Developing Countries

Mjesto i datum
Cavtat, Hrvatska, 20.09.2006. - 24.09.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ethylmercury; inorganic mercury; tissue distribution; rats

Sažetak
Thiomersal (ethylmercury) used as preservative in vaccines represents a new aspect in the field of mercury toxicity. Given to infants during the vaccination period it might cause neurotoxic effect. Since data on the toxicokinetics of ethylmercury in the very young are scarce, we investigated the difference in distribution between two forms of mercury, ethylmercury and mercuric chloride in suckling rats. In our experimental model organic and inorganic mercury were administered three times during the suckling period (on days 7, 9 and 11after birth) by subcutaneous injection and at a dose of 0.81 μ mol Hg kg− 1 body weight. At the end of the experiment 72 h after the last treatment, total mercury was analysed in blood and organs (liver, kidneys, brain) by the method amalgamation and atomic absorption spectrometry. In the Thiomersal group as compared to the inorganic mercury group, concentrations of total mercury were higher in blood (23 times) and brain (1.5 times) and lower in the kidney (4 times) and liver (1.3 times). Further studies on mercury kinetics of Thiomersal treated sucklings are in progress.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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