The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study

Jakovljević, Miro; Pivac, Nela; Mihaljević-Peleš, Alma; Mustapić, Maja; Relja, Maja; Ljubičić, Đulijano; Marčinko, Darko; Muck-Šeler, Dorotea

doi:10.1016/j.pnpbp.2006.10.007

Pregled bibliografske jedinice broj: 259458

The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study

Jakovljević, Miro; Pivac, Nela; Mihaljević-Peleš, Alma; Mustapić, Maja; Relja, Maja; Ljubičić, Đulijano; Marčinko, Darko; Muck-Šeler, Dorotea

The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study // Progress in Neuro-psychopharmacology and Biological Psychiatry, 31 (2007), 2; 399-402 doi:10.1016/j.pnpbp.2006.10.007 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 259458 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study

Autori
Jakovljević, Miro ; Pivac, Nela ; Mihaljević-Peleš, Alma ; Mustapić, Maja ; Relja, Maja ; Ljubičić, Đulijano ; Marčinko, Darko ; Muck-Šeler, Dorotea

Izvornik
Progress in Neuro-psychopharmacology and Biological Psychiatry (0278-5846) 31 (2007), 2; 399-402

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cortisol; fluphenazine; olanzapine; prolactin; rigidity; schizophrenia

Sažetak
Pharmacotherapy of schizophrenia is associated with the stressful side effects. Muscle rigidity causes distress, discomfort and poor compliance. The aim of the study was to determine the relationship between plasma hormones (cortisol and prolactin /PRL/) and muscle rigidity in female schizophrenic patients treated with olanzapine or fluphenazine. In a randomized, double-blind 22-weeks study, 12 patients were treated with olanzapine (5-20 mg/day) and 10 patients received fluphenazine (6-21 mg/day). Treatment with olanzapine moderately decreased, while treatment with fluphenazine significantly increased plasma cortisol levels and muscle rigidity. The marked and moderate increase in plasma PRL levels were found in patients treated with fluphenazine and olanzapine, respectively. The results suggested that olanzapine induced moderate neuroendocrine effects and a reduction in rigidity as compared to fluphenazine treatment.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
098088
062-0982522-0069 - Klinički i biološki pokazatelji generaliziranog anksioznog i paničnog poremećaja (Ljubičić, Đulijano, MZOS ) ( CroRIS)
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( CroRIS)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( CroRIS)
108-1080037-0323 - Multidimenzionalna analiza bioloških pokazatelja u duševnim poremećajima (Jakovljević, Miro, MZOS ) ( CroRIS)