Naslov
Familial reccurence and inheritance of multiple sclerosis in the western Croatia

Autori
Ristić, Smiljana ; Sepčić, Juraj ; Kapović, Miljenko ; Brajenović-Milić, Bojana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of the 13th Congress of the European Committee for Treatment and Research in Multiple Sclerosis : ECTRIMS 97 : Multiple sclerosis. Clinical and Laboratory Research / Allen, Ingrid V - Avenel (NJ) : Stockton press, 1997, 323-323

Skup
ECTRIMS 97 : Congress of the European Committee for Treatment and Research in Multiple Sclerosis (13 ; 1997)

Mjesto i datum
Istanbul, Turska, 02.11.1997. - 05.11.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Multiple sclerosis; Genetic; Epidemiology

Sažetak
The aim of this study was to explore familiality as well as the heritability and possible mode of inheriting susceptibility to multiple sclerosis in a sample of 105 MS patients from Western Croatia. In determining the patients diagnosis the Posers criteria for clinicaly definite and laboratory supported definite MS was applied. A control group was formed by the method of individual matching, where for each patient a healthy subject of the same sex, age and living was chosen. Assesment of the pattern of MS susceptibility inheritance was performed by detailed pedigree analysis and methods of quantitative genetics according to Falconer. Family history for at least one relative with MS was positive in 11.4 percent of families of MS patients and in 2.9 percent families of controls. The differnce was significant by McNemars test. The greater the distance between degrees from relationship, the lower the incidence of the disease in the relatives of affected persons, 1:76, 1:225 and 1:441 in relatives of degree I, II and III, respectively, which considerably exceeded the incidence of the disease in the relatives of healthy subjects, 1:564, 1:871 and 1:1012 in relatives of degree I, II and III, respectively. The values of heritability coefficients in first, second and third degree relatives did not differ greatly among themselves, suggesting a role of the genetic component in MS etiology.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA