Pregled bibliografske jedinice broj: 259107
VIBRATIONAL AND ELECTRONIC SPECTRAL CHARACTERISATION OF SEVERAL PHARMACOLOGICALLY IMPORTANT ARALKYL DERIVATIVES OF THE PYRIDINIUM CATION
VIBRATIONAL AND ELECTRONIC SPECTRAL CHARACTERISATION OF SEVERAL PHARMACOLOGICALLY IMPORTANT ARALKYL DERIVATIVES OF THE PYRIDINIUM CATION // XXVIII EUROPEAN CONGRESS ON MOLECULAR SPECTROSCOPY ; BOOK OF ABSTRACTS / Akyuz, Sevim ; Akalin, Elif (ur.).
Istanbul, 2006. str. 152-152 (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 259107 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
VIBRATIONAL AND ELECTRONIC SPECTRAL CHARACTERISATION OF SEVERAL PHARMACOLOGICALLY IMPORTANT ARALKYL DERIVATIVES OF THE PYRIDINIUM CATION
Autori
Foretić, Blaženka ; Lovrić, Jasna ; Picek, Igor ; Burger, Nicoletta
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
XXVIII EUROPEAN CONGRESS ON MOLECULAR SPECTROSCOPY ; BOOK OF ABSTRACTS
/ Akyuz, Sevim ; Akalin, Elif - Istanbul, 2006, 152-152
Skup
XXVIII EUROPEAN CONGRESS ON MOLECULAR SPECTROSCOPY
Mjesto i datum
Istanbul, Turska, 03.09.2006. - 08.09.2006
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
FT IR and Raman spectroscopy; UV-VIS spectroscopy; 1-Phenacyl- and 1-Benzoylethylpyridinium derivatives
Sažetak
Pyridinium or bispyridinium oxime derivatives are known as potent acetylcholinesterase reactivators used for the prophylaxis and treatment of intoxications with organophosphorous compounds such as nerve agents and pesticides. Some 1-phenacylpyridinium salts have interesting antifungal and amebacidal properties while 1-benzoylethylpyridinium and 1-benzoylethylpyridinium-4-aldoxime salts act as possible protectors of human blood cholinesterase due to their capability to reversibly inhibit this enzyme. The spectrophotometric studies on the coordination ability of the selected aralkyl derivatives of the pyridinium cation (Table 1) to the pentacyanoferrate(II) moiety have shown considerable differences concerning their stability and reactivity in aqueous solutions. These findings encouraged us to perform a comparative FT IR and FT Raman spectroscopic study of the solid compounds focused on their structural features. Table 1. The examined derivatives of pyridinium chloride Name R1 R2 1-Phenacylpyridinium chloride -CH2- -H 1-Phenacyl-2-methylpyridinium chloride -CH2--CH3 1-Phenacylpyridinium-4-aldoxime chloride-CH2- -C=N-OH 1-Benzoylethylpyridinium chloride -CH2CH2- -H 1-Benzoylethylpyridinium-4-aldoxime chloride -CH2CH2- -C=N-OH The characteristic vibrational frequencies will be discussed in correlation to their predominant keto-enol form, acido-basic properties, and in comparison with the electronic spectra of the ligands themselves and their pentacyanoferrate(II) complexes.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
